Barium ion cross-linked alginate-carboxymethyl cellulose composites for controlled release of anticancer drug methotrexate

Kahya N., Gölcü A., Erim F. B.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, cilt.54, 2019 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 54
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1016/j.jddst.2019.101324
  • Dergi Adı: JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: Polysaccharides, Biopolymers, Drug release, Drug delivery, Cellulose, Metal complex, IN-VITRO RELEASE, BEADS, POLYSACCHARIDES, DELIVERY, NANOPARTICLES, CHITOSAN
  • İstanbul Teknik Üniversitesi Adresli: Evet

Özet

In the present study, sodium alginate (NaAlg)/sodium carboxymethyl cellulose (NaCMC) composite hydrogel beads were prepared by cross-linking with barium chloride solution. The degree of swelling and the release profile of methotrexate (MTX) from the beads were investigated under phosphate buffer saline (PBS) condition (pH = 7.4 at 37 degrees C). Since the water solubility of MTX is low, the drug was dissolved in the green solvent DMSO and added to the polymer solution. The existence of DMSO (10% v/v) significantly affected the morphology, swelling, and release profiles of the beads. Scanning electron microscopy (SEM) and Fourier transformed infrared spectroscopy (FTIR) analysis were performed to characterize the Ba-Alg/CMC composites. The results showed that almost the total amount of MTX release (98.1 +/- 2.64%) was completed in 5 h. Moreover, synthesized Cu(II) (MXT-Cu) and Zn(II) (MXT-Zn) metal complexes of MTX were loaded to Ba-Alg/CMC beads and subjected to drug release studies. Entrapment efficiency (EE%) and release behaviors of the metal complexes of MTX were compared to MTX. The mostly used drug release kinetic models which are first order, Higuchi and Hixson-Crowell were applied to release data.