Natural alginate biopolymer montmorillonite clay composites for vitamin B2 delivery

KAYGUSUZ H., UYSAL M., Adımcılar V., Erim F. B.

JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS, cilt.30, sa.1, ss.48-56, 2015 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 30 Sayı: 1
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1177/0883911514557014
  • Dergi Adı: JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.48-56
  • Anahtar Kelimeler: Riboflavin, alginate, biopolymer, release, montmorillonite, CONTROLLED-RELEASE, DYNAMIC RELEASE, DRUG-DELIVERY, IN-VITRO, RIBOFLAVIN, BEADS, SYSTEM
  • İstanbul Teknik Üniversitesi Adresli: Evet

Özet

This work describes the in vitro release of a small drug, riboflavin, from novel calcium and barium crosslinked alginate-montmorillonite composite beads via oral route. Effect of crosslinking cation, concentration of montmorillonite and media on encapsulation efficiencies, and release profiles of riboflavin were studied. Beads were characterized using gravimetric swelling ability study, Fourier transform infrared spectroscopy, and scanning electron microscopy. Results indicate that addition of montmorillonite increases the encapsulation efficiencies and slows down the release rates significantly.