Enhancing magnetic resonance imaging tumor detection with fluorescence intensity and lifetime imaging

Erten A. C., HALL D., HOH C., Cao H. S. I., KAUSHAL S., ESENER S., ...Daha Fazla

JOURNAL OF BIOMEDICAL OPTICS, cilt.15, sa.6, 2010 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 15 Sayı: 6
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1117/1.3509111
  • Dergi Adı: JOURNAL OF BIOMEDICAL OPTICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • İstanbul Teknik Üniversitesi Adresli: Hayır

Özet

Early detection is important for many solid cancers but the images provided by ultrasound, magnetic resonance imaging (MRI), and computed tomography applied alone or together, are often not sufficient for decisive early screening/diagnosis. We demonstrate that MRI augmented with fluorescence intensity (FI) substantially improves detection. Early stage murine pancreatic tumors that could not be identified by blinded, skilled observers using MRI alone, were easily identified with MRI along with FI images acquired with photomultiplier tube detection and offset laser scanning. Moreover, we show that fluorescence lifetime (FLT) imaging enables positive identification of the labeling fluorophore and discriminates it from surrounding tissue autofluorescence. Our data suggest combined-modality imaging with MRI, H, and FLT can be used to screen and diagnose early tumors. (C) 2010 Society of Photo-Optical Instrumentation Engineers. [DOI: 10.1117/1.3509111]