Fabrication and characterization of electrospun biopolyester/gelatin nanofibers

Ülker Turan C., Guvenilir Y.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, cilt.109, sa.10, ss.1478-1487, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 109 Sayı: 10
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1002/jbm.b.34807
  • Dergi Adı: JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, PASCAL, Aerospace Database, Applied Science & Technology Source, BIOSIS, Biotechnology Research Abstracts, Chemical Abstracts Core, Chimica, Communication Abstracts, Compendex, Computer & Applied Sciences, EMBASE, INSPEC, MEDLINE, Metadex, Civil Engineering Abstracts
  • Sayfa Sayıları: ss.1478-1487
  • İstanbul Teknik Üniversitesi Adresli: Evet

Özet

Poly(omega-pentadecalactone-co-epsilon-caprolactone) copolymer (PDL-CL) is an enzymatically synthesized aliphatic biopolyester, which has been participated in a nanofibrous structure for the first time. Electrospinning of this synthetic polymer by blending with a natural polymer such as gelatin (Gel) could provide new characteristics that are significant for biomedical applications, such as drug delivery, wound healing, and tissue engineering. In the present study, PDL-CL/Gel nanofibrous membranes were successfully produced and characterized. The average diameter of nanofibers was 305.0 +/- 45.5 nm that may be beneficial in applications mentioned above. In order to increase hydrolytic resistance, cross-linking with glutaraldehyde vapor was applied. Cross-linking for 2 h was enough to obtain a nanofibrous membrane that was able to resist in pH 7.4 phosphate buffered saline for 30 days. In addition, contact angle measurement results had shown that, cross-linked nanofibrous membrane had good wettability, which is a required specification to be applied in biomedical field. Hence, this study provides an overview on fabrication of fine PDL-CL/Gel nanofibers, which may have potential to be used in biomedical area.