Environmentally friendly composites are increasingly used in building applications that require fungal and insect resistance. This study evaluated the ability of both wood-degrading and mold fungi to decompose hybrid composites made of wood furnish, glass fibers, and jute fabric skin. Fungal decay resistance tests employed brown-rot fungus (Fomitopsis palustris) and white-rot fungus (Trametes versicolor). Mold resistance tests were performed with a mixture of three mold fungi, Aspergillus niger, Penicillium chrysogenum, and Trichoderma viride. The test specimens were also bio-assayed against termites in both laboratory and field conditions. When compared to control composites specimens produced by conventional methods without glass fiber and jute, the specimens with/without glass fiber and jute fabric manufactured by the VARTM process showed high resistance against the wood-degrading fungi and termites under laboratory and field conditions; however, mold fungal growth was observed on the surfaces of the specimens with 10%, 15%, and 20% glass fiber (without jute fabric) and with 5%, 10%, and 15% glass fiber (with jute fabric). In geographical locations with severe decay and termite hazards, these composite products may have a long service life as alternatives to conventional composites.