In this study, a new CMOS differential operational transresistance amplifier (OTRA) topology is proposed. This topology can operate with a very low voltage power supply as 1.2 V. In this design, CMOS 0.13 mu m STMicroelectronics technology transistor models are used for the simulations. The designed CMOS OTRA has a transresistance gain (Rm) of 38 660 V/A with a bandwidth (-3 dB) of 29.2 MHz. To demonstrate the performance of the OTRA, designed universal MOS-C filter employing two CMOS differential OTRA are tested with CADENCE simulation program to verify the theoretical results. (C) 2006 Elsevier GmbH. All rights reserved.