Silver Nanoparticle-Coated Polyhydroxyalkanoate Based Electrospun Fibers for Wound Dressing Applications

Kalaoglu-Altan Ö. İ., Baskan H., Meireman T., Basnett P., Azimi B., Fusco A., ...More

MATERIALS, vol.14, no.17, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 14 Issue: 17
  • Publication Date: 2021
  • Doi Number: 10.3390/ma14174907
  • Journal Name: MATERIALS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, CAB Abstracts, Communication Abstracts, Compendex, INSPEC, Metadex, Veterinary Science Database, Directory of Open Access Journals, Civil Engineering Abstracts
  • Keywords: polyhydroxyalkanoates, eco-friendly nanofibers, wound dressings, low-impact biomedical applications, immunomodulation, defensin, keratinocytes, IN-SITU PREPARATION, NANOFIBROUS SCAFFOLDS, PHB BIOPOLYMER, POLYMERS, EXTRACTION, CELLS, POLY(3-HYDROXYBUTYRATE), SOLUBILITY, PARAMETERS, REDUCTION
  • Istanbul Technical University Affiliated: Yes


Wound dressings are high performance and high value products which can improve the regeneration of damaged skin. In these products, bioresorption and biocompatibility play a key role. The aim of this study is to provide progress in this area via nanofabrication and antimicrobial natural materials. Polyhydroxyalkanoates (PHAs) are a bio-based family of polymers that possess high biocompatibility and skin regenerative properties. In this study, a blend of poly(3-hydroxybutyrate) (P(3HB)) and poly(3-hydroxyoctanoate-co-3-hydroxy decanoate) (P(3HO-co-3HD)) was electrospun into P(3HB))/P(3HO-co-3HD) nanofibers to obtain materials with a high surface area and good handling performance. The nanofibers were then modified with silver nanoparticles (AgNPs) via the dip-coating method. The silver-containing nanofiber meshes showed good cytocompatibility and interesting immunomodulatory properties in vitro, together with the capability of stimulating the human beta defensin 2 and cytokeratin expression in human keratinocytes (HaCaT cells), which makes them promising materials for wound dressing applications.