Hyperspectral image classification via supervised approaches is often affected by the high dimensionality of the spectral signatures and the relative scarcity of training samples. Dimensionality reduction (DR) and active learning (AL) are two techniques that have been investigated independently to address these two problems. Considering the nonlinear property of the hyperspectral data and the necessity of applying AL adaptively, in this paper, we propose to integrate manifold and active learning into a unique framework to alleviate the aforementioned two issues simultaneously. In particular, supervised Isomap is adopted for DR for the training set, followed by an out-of-sample extension approach to project the large amount of unlabeled samples into previously learned embedding space. Finally, AL is performed in conjunction with k-nearest neighbor (kNN) classification in the embedded feature space. Experiments on a benchmark hyperspectral dataset illustrate the effectiveness of the proposed framework in terms of DR and the feature space refinement.