The sinistral Malatya-Ovack Fault Zone (MOFZ) is one of the outstanding intraplate deformation belts within Anatolia. The 165-km-long, NE-SW-striking Malatya Fault (MF), which constitutes the southern section of the MOFZ, is separated into five segments according to its surface geometry. These segments have evident morphotectonic features that reflect long- and short-term fault activity, such as morphologic structures offset by as little as 7m and as much as 7.3km. This study provides results from the first paleoseismological investigations on the MF. We find that the last earthquake occurred between 965 and 549 BCE and calculate a recurrence interval of 2275 +/- 605years from evidence for four paleo-events over the last 10ka. Considering fault segmentation and our paleoseismological data, we propose that the accumulated strain on the MF may cause a destructive earthquake (M=7.4) in the near future. Our results support the hypotheses that the MF and other NW-striking dextral and NE-striking sinistral strike-slip faults within the eastern part of Anatolia are plate boundary-related, active deformational structures.