CXCR4-Targeted Nanocarriers for Triple Negative Breast Cancers

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Misra A. C., Luker K. E., Durmaz H., Luker G. D., LAHANN J.

BIOMACROMOLECULES, cilt.16, sa.8, ss.2412-2417, 2015 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 16 Sayı: 8
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1021/acs.biomac.5b00653
  • Dergi Adı: BIOMACROMOLECULES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.2412-2417
  • İstanbul Teknik Üniversitesi Adresli: Hayır

Özet

CXCR4 is a cell membrane receptor that is overexpressed in triple-negative breast cancers and implicated in growth and metastasis of this disease. Using electrohydrodynamic cojetting, we prepared multicompartmental drug delivery carriers for CXCR4 targeting. The particles are comprised of a novel poly(lactide-co-glycolide) derivative that allows for straightforward immobilization of 1,1'[1,4-phenylenebis(methylene)This[1,4,8,11-tetraazacyclotetradecane] (Plerixafor), a small molecule with affinity for CXCR4. Targeted nanocarriers are selectively taken up by CXCR4-expressing cells and effectively block CXCR4 signaling. This study suggests that CXCR4 may be an effective target for nanocarrier-based therapies.