Trade has been one of the main factors affecting political relations and cultural exchange between countries inevery period of history, especially in the periods when communication technologies have not developed as muchas today. Cultural exchange, which has influenced many areas from art to technology, has also affectedarchitecture. Within the scope of this study, aims to examine the reflections of political relations, that aredeveloped for the protection of commercial interests, on cultural exchange in the context of architecturalstructures of the Ottoman Empire and the Republic of Venice, which are generally divided into two parts as east-west in histography although sharing the same Mediterranean geography, are discussed. However, the study islimited to the 16th century, during the relations between these two important political powers lived their mostinfluential periods, and the reflections are examined through the structures of the important architects of thatperiod, Mimar Sinan and Andrea Palladio. In the first part of the study, the relationship between Venetian bailoMarc 'Antonio Barbaro and Grand Vizier Sokullu Mehmed Pasha, which is believed to form an invisible bridgebetween the two architects, is examined based on the literature on the subject. In the other phase of the study, a
timeline has been created shows the chronological order of the architects’ prominent works and was divided into
two according to the years he was in Constantinople to see whether Barbaro affected these works. The structuresdesigned by these architects were compared in terms of plan typology, structural solutions, and facadecharacteristics according to the distinction before and after Barbaro. At the end of the study was concluded thatthe compared works of these two important architects, who had not seen each other's buildings personally, wereseparated from the previous ones in line with distinct features and these features were some aspects thatresemble the style of the other architect. As a result, this supports the argument that Barbaro, who has taken on apolitical role to balance the two political forces, also has an important place in intercultural exchange.