Synthesis and characterization of novel quatemized 2, 3-(diethylmethylamino)phenoxy tetrasubstituted Indium and Gallium phthalocyanines and comparison of their antimicrobial and antioxidant properties with different phthalocyanines


ŞAKİ N., Akin M., Atsay A., Karaoglu H. R., Koçak M.

INORGANIC CHEMISTRY COMMUNICATIONS, vol.95, pp.122-129, 2018 (SCI-Expanded) identifier identifier

Abstract

In this work, we describe the synthesis and characterization of tetra-substituted 2,9(10),16(17),23(24)-tetrakis-[3-(diethylmethylamino)phenoxy) phthalocyaninatochlorogallium (III) tetraiodide and 2,9(10),16(17),23(24)-tetrakis-[3-(diethylmethylamino)phenoxy) phthalocyaninatochloroindium (III) tetraiodide and comparision of their antioxidant and antimicrobial activities with previously synthesized metallo- or metal-free octa-substituted phthalocyanines bearing diethylaminophenoxy groups at peripheral positions. Antioxidant activities of the compounds were investigated by using DPPH free radical scavenging assay, beta-carotene/linoleic acid bleaching assay and reducing power assay and no significant difference was observed between metal-containing and metal-free phthalocyanine compounds. Disc diffusion and macro dilution methods were used to determine the antimicrobial activities of the PCs on Gram-negative and Gram-positive bacteria and newly synthesized tetra-cationic gallium (PC6) and indium (PC7) phthalocyanines showed antimicrobial activity against all tested microorganisms. Antibacterial activity of neutral compounds was considerably lower or even negligible than that of cationic ones.