Purpose - Cancer is the foremost disease that causes death. The objective of hyperthermia in cancer therapy is to raise the temperature of cancerous tissue above a therapeutic value while maintaining the surrounding normal tissue at sublethal temperature values in cases where surgical intervention is dangerous or impossible. The malignant tissue is heated up to 42 degrees C in the treatment. In this method, the unaffected tissues are aimed to have minimum damage, while the affected ones are destroyed. Therefore, it is very important for the optimization of the method to know the temperature profiles in both tissues. Accurately estimating the tissue temperatures has been a very important issue for tumor hyperthermia treatment planning. This paper, proposes to theoretically predict the temperature response of the biological tissues subject to external EM heating by using the space-dependent blood perfusion term in Pennes bio-heat equation.