Phenolic compounds as natural microbial toxin detoxifying agents

Saricaoglu B., GÜLTEKİN SUBAŞI B., Karbancıoğlu Güler H. F., Lorenzo J. M., Çapanoğlu Güven E.

Toxicon, vol.222, 2023 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Review
  • Volume: 222
  • Publication Date: 2023
  • Doi Number: 10.1016/j.toxicon.2022.106989
  • Journal Name: Toxicon
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, CAB Abstracts, Chemical Abstracts Core, Communication Abstracts, EMBASE, Environment Index, MEDLINE, Metadex, Pollution Abstracts, Veterinary Science Database, Civil Engineering Abstracts
  • Keywords: Aflatoxin, Bacterial toxins, Cholera toxin, Mycotoxins, Phenolic acid
  • Istanbul Technical University Affiliated: Yes


© 2022 Elsevier LtdDespite the abundance of promising studies, developments, and improvements about the elimination of microbial toxins from food matrices, they are still considered as one of the major food safety problems due to the lack of their complete avoidance even today. Every year, many crops and foodstuffs have to be discarded due to unconstrained contamination and/or production of microbial toxins. Furthermore, the difficulty for the detection of toxin presence and determination of its level in foods may lead to acute or chronic health problems in many individuals. On the other hand, phenolic compounds might be considered as microbial toxin detoxification agents because of their inhibition effect on the toxin synthesis of microorganisms or exhibiting protective effects against varying damaging mechanisms caused by toxins. In this study, the effect of phenolic compounds on the synthesis of bacterial toxins and mycotoxins is comprehensively reviewed. The potential curing effect of phenolic compounds against toxin-induced damages has also been discussed. Consequently, phenolic compounds are indicated as promising, and considerable natural preservatives against toxin damages and their detoxification potentials are pronounced.