ENHANCEMENT OF THE SOLUBILITY OF HERBAL POLYPHENOLIC COMPOUNDS IN THE PRESENCE OF LACTIC ACID BUTYLETHER PEG (200)


YILDIZ G., ŞENKAL B. F., TEKNECİ E.

Sigma Journal of Engineering and Natural Sciences, vol.37, no.4, pp.1219-1229, 2019 (ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 37 Issue: 4
  • Publication Date: 2019
  • Journal Name: Sigma Journal of Engineering and Natural Sciences
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Academic Search Premier, Directory of Open Access Journals
  • Page Numbers: pp.1219-1229
  • Keywords: Curcumin, morin, emulsion, water solubility, lactic acid ester of butylether PEG (200), MORIN HYDRATE, CURCUMIN, ABSORPTION, MECHANISM, DELIVERY, AGENT
  • Istanbul Technical University Affiliated: Yes

Abstract

Polyphenolic compounds found in some plants are very important for human health because of their antioxidant and some disease healing properties. However polyphenolic compounds have a disadvantage that their bioavailability is low due to their low solubility in water. In this study, a new PEG derivative, lactic acid ester of butylether PEG 200 (PEG-ester) has been synthesized and then it has been interacted with curcumin and morin to improve poor water solubility of these polyphenolic compounds. PEG ester, was found to be miscible with water and significantly improved the water solubility of curcumin and morin. The characterization of emulsion systems formed with PEG-ester in the presence of curcumin and morin were investigated. The amount of curcumin and morin in emulsion systems was carried out by UV/VIS spectrophotometric measurements. Interactions were characterized by FTIR measurements. Solubility and stability studies were performed.