Diet, Lifestyle and Cardiovascular Diseases: Linking Pathophysiology to Cardioprotective Effects of Natural Bioactive Compounds

Sharifi-Rad J., Rodrigues C. F., Sharopov F., Docea A. O., Can Karaça A., Sharifi-Rad M., ...More

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, vol.17, no.7, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 17 Issue: 7
  • Publication Date: 2020
  • Doi Number: 10.3390/ijerph17072326
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus, Agricultural & Environmental Science Database, Aqualine, Aquatic Science & Fisheries Abstracts (ASFA), CAB Abstracts, EMBASE, Geobase, MEDLINE, Pollution Abstracts, Veterinary Science Database, Directory of Open Access Journals
  • Keywords: food, diet, lifestyle, classical and emerging risk factors, atherosclerosis, arterial hypertension, diabetes, coronary artery disease, plant-food bioactive compounds, cardio-protective pharmacotherapy, POLYUNSATURATED FATTY-ACIDS, ANGIOTENSIN-CONVERTING ENZYME, CORONARY-HEART-DISEASE, REDUCING CARDIOMETABOLIC DISEASE, VIRGIN OLIVE OIL, BLOOD-PRESSURE, IN-VITRO, DOUBLE-BLIND, EICOSAPENTAENOIC ACID, CALORIE RESTRICTION
  • Istanbul Technical University Affiliated: Yes


Heart and blood vessels disorders comprise one of the main causes of death worldwide. Pharmacologically active natural compounds have been used as a complementary therapy in cardiovascular disease around the world in a traditional way. Dietary, natural bioactive compounds, as well as healthy lifestyles, are considered to prevent coronary artery diseases. Pre-clinical and clinical studies reported that consumption of plant-food bioactive derivatives including polyphenolic compounds, peptides, oligosaccharides, vitamins, unsaturated fatty acids possess protective effects on cardiovascular diseases. This review aims to summarize the cardiovascular risk factors, pre-clinical studies and clinical trials related to cardioprotective properties of the plant-food-derived bioactive compounds. Molecular mechanisms by the natural bioactive compounds exert their cardiovascular protective properties have also been highlighted.