Diet, Lifestyle and Cardiovascular Diseases: Linking Pathophysiology to Cardioprotective Effects of Natural Bioactive Compounds


Sharifi-Rad J., Rodrigues C. F. , Sharopov F., Docea A. O. , Can Karaça A. , Sharifi-Rad M., ...More

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, vol.17, no.7, 2020 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 17 Issue: 7
  • Publication Date: 2020
  • Doi Number: 10.3390/ijerph17072326
  • Title of Journal : INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
  • Keywords: food, diet, lifestyle, classical and emerging risk factors, atherosclerosis, arterial hypertension, diabetes, coronary artery disease, plant-food bioactive compounds, cardio-protective pharmacotherapy, POLYUNSATURATED FATTY-ACIDS, ANGIOTENSIN-CONVERTING ENZYME, CORONARY-HEART-DISEASE, REDUCING CARDIOMETABOLIC DISEASE, VIRGIN OLIVE OIL, BLOOD-PRESSURE, IN-VITRO, DOUBLE-BLIND, EICOSAPENTAENOIC ACID, CALORIE RESTRICTION

Abstract

Heart and blood vessels disorders comprise one of the main causes of death worldwide. Pharmacologically active natural compounds have been used as a complementary therapy in cardiovascular disease around the world in a traditional way. Dietary, natural bioactive compounds, as well as healthy lifestyles, are considered to prevent coronary artery diseases. Pre-clinical and clinical studies reported that consumption of plant-food bioactive derivatives including polyphenolic compounds, peptides, oligosaccharides, vitamins, unsaturated fatty acids possess protective effects on cardiovascular diseases. This review aims to summarize the cardiovascular risk factors, pre-clinical studies and clinical trials related to cardioprotective properties of the plant-food-derived bioactive compounds. Molecular mechanisms by the natural bioactive compounds exert their cardiovascular protective properties have also been highlighted.