First and second order slip flow models in rectangular microchannels heated at constant and uniform wall temperature are studied. The velocity and temperature profiles for hydrodynamically and thermally developed incompressible slip flow regime available in literature are used. The average nondimensional slip velocity and temperature jump are found by using first and second order slip flow models. The average Nusselt number is also derived by using both first and second order slip flow models. The effects of Knudsen number, aspect ratio and second order slip flow model on the heat transfer characteristics of microchannel are explored.