This paper is concerned with the theoretical analysis of the isotropic plates exposed to normal blast shock waves as well as presenting correlation between the theoretical analysis and the experimental results of the strain-time histories. The plate is clamped at its all edges. On the theoretical side of the study, the equations of motion of the isotropic plate are derived by the use of the virtual work principle within the framework of Love's theory of thin elastic shells. The governing equations of the plate are solved by the Runge-Kutta-Verner method. On the experimental side of the study, the plate tests have been carried out on the isotropic plates with clamped edges for blast loading. Furthermore, a finite element modeling and analysis are presented and experimental results are compared with the results of theoretical method and finite element method. As well, the effects of material properties are examined on the dynamic behavior.