This study aims to explore the relationship between compression bandage (CB) and muscles' performance. Hand wrist, mid-calf, and ankle muscles are subjected to electrical voltage test with and without wearing CB. Electromyography (EMG) analysis is a substantial component often used for the assessment of muscles activity. Flexor Carpi (FC), Medial Gastrocnemius (MG), and Soleus (SO) muscles are selected to represent wrist, mid-calf, and ankle muscles respectively. The standardized activities protocol used to test FC muscles are (flexion-extension and squeezing a soft roll), while the activities for MG and SO muscles are (flexion-extension and while walking). The obtained data are analyzed using Mega-win and Mat-lab software. Wearing CB was associated with significantly lower muscle activation and higher median frequency for MG and SO muscles during different actions. These results suggest that using CB can improve muscles function, which might enhance walking performance and reduce muscles fatigue.