Functional poly(p-phenylene)s as targeting and drug carrier materials


Guler B., Akbulut H., GEYİK C., Barlas F. B. , ODACI DEMİRKOL D., COŞKUNOL H., ...Daha Fazla

INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS, cilt.65, ss.653-659, 2016 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 65 Konu: 13
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1080/00914037.2016.1157797
  • Dergi Adı: INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
  • Sayfa Sayıları: ss.653-659

Özet

Polymers have a substantial attention in drug delivery systems owing to the diverse intrinsic advantages. It is important to carry the drug to the target site and release to exert its effects. Herein, poly(p-phenylene)s with amino and poly(ethylene glycol) substituents (PPP-NH2-g-PEG) were used as a carrier for doxorubicin (DOX), an anticancer drug, and haloperidol, a sigma receptor targeting ligand. Both human cervix adenocarcinoma cell line (HeLa) and human keratinocyte cell line (HaCaT) having different Sigma receptor 1 (SigmaR1) expression levels were compared. HeLa was found to express twofold SigmaR1 compared to HaCaT cells. Cell imaging studies showed that, DOX cell uptake was higher in HeLa cells when targeted with haloperidol.