Functional poly(p-phenylene)s as targeting and drug carrier materials

Guler, Bahar; Akbulut, Huseyin; GEYİK, CANER; Barlas, F.; ODACI DEMİRKOL, DİLEK; COŞKUNOL, HAKAN; TİMUR, SUNA; Yagci, Yusuf

doi:10.1080/00914037.2016.1157797

Functional poly(p-phenylene)s as targeting and drug carrier materials

Guler B., Akbulut H., GEYİK C., Barlas F. B., ODACI DEMİRKOL D., COŞKUNOL H., ...Daha Fazla

INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS, cilt.65, sa.13, ss.653-659, 2016 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 65 Sayı: 13
Basım Tarihi: 2016
Doi Numarası: 10.1080/00914037.2016.1157797
Dergi Adı: INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.653-659
İstanbul Teknik Üniversitesi Adresli: Evet

Özet

Polymers have a substantial attention in drug delivery systems owing to the diverse intrinsic advantages. It is important to carry the drug to the target site and release to exert its effects. Herein, poly(p-phenylene)s with amino and poly(ethylene glycol) substituents (PPP-NH2-g-PEG) were used as a carrier for doxorubicin (DOX), an anticancer drug, and haloperidol, a sigma receptor targeting ligand. Both human cervix adenocarcinoma cell line (HeLa) and human keratinocyte cell line (HaCaT) having different Sigma receptor 1 (SigmaR1) expression levels were compared. HeLa was found to express twofold SigmaR1 compared to HaCaT cells. Cell imaging studies showed that, DOX cell uptake was higher in HeLa cells when targeted with haloperidol.