Since less air circulation occurs at feet in shoes than the other parts of the body, many people have foot-related problems as a result of faulty sock choice. Socks are generally expected to have better comfort properties than the other garments, and accordingly the industry continuously searches for various types of raw materials in order to accomplish the consumers' comfort-related demands. In this study, our aim was to investigate the comfort properties of socks made from seacell fiber, which has a relatively wide range of application in medical textiles due to its skin and anti-inflammatory properties. For comparison reasons, the comfort properties of socks made from modal, bamboo, soybean cotton, and viscose fibers were also studied. Finally, the hybrid AHP-TOPSIS method was used to decide the best sock option in terms of the properties under discussion.