Lithium-ion batteries are extensively used, not only for their advantages of high specific energy and durability but also for their light weight and robust structures, in many applications of space equipment, where severe mechanical vibration and shock conditions are encountered, especially during the launch, climb and stationing on the determined orbit. To design a robust battery pack that can withstand such loading conditions, a comprehensive investigation into the effects of such circumstances must be carried out both experimentally and computationally. In this study, four different battery topologies complying with the electrical requirements were compared according to various performance indicators. Then, the best prototype of the alternatives was chosen. The selected lithium-ion battery pack was examined with the help of resonance, harmonic and random vibration tests that were implemented according to the ECSS (European Cooperation for Space Standardization) standards. Additionally, a finite element model of the pack was prepared, and vibration simulations were run and compared with the experimental results. In the experimental work, it was observed that the battery-pack retained its structural integrity without experiencing any kind of mechanical failures. It was also observed that the outcomes of the finite element simulations are reasonably consistent with the test results.