Pyridine and benzene templated potential peptidomimetics


Dabak K.

TURKISH JOURNAL OF CHEMISTRY, vol.26, no.6, pp.955-963, 2002 (Journal Indexed in SCI) identifier

  • Publication Type: Article / Article
  • Volume: 26 Issue: 6
  • Publication Date: 2002
  • Title of Journal : TURKISH JOURNAL OF CHEMISTRY
  • Page Numbers: pp.955-963

Abstract

This study provides a new approach for the synthesis of pyridine and benzene templated potential peptidomimetics. By the attachment of various amino acid side chains in different combinations on the pyridine template at the 2- and 3- positions and on the benzene core at 1,2,4 positions, different peptidomimetics may be obtained. Arg-10, Leu-11 and Tyr-13 amino acid side chain mimics and their precursors were attached to the pyridine and benzene core with a special arrangement to produce potential peptidomimetics of omega-conotoxin MVIIA.