Pyridine and benzene templated potential peptidomimetics


Dabak K.

TURKISH JOURNAL OF CHEMISTRY, cilt.26, ss.955-963, 2002 (SCI İndekslerine Giren Dergi) identifier

  • Cilt numarası: 26 Konu: 6
  • Basım Tarihi: 2002
  • Dergi Adı: TURKISH JOURNAL OF CHEMISTRY
  • Sayfa Sayıları: ss.955-963

Özet

This study provides a new approach for the synthesis of pyridine and benzene templated potential peptidomimetics. By the attachment of various amino acid side chains in different combinations on the pyridine template at the 2- and 3- positions and on the benzene core at 1,2,4 positions, different peptidomimetics may be obtained. Arg-10, Leu-11 and Tyr-13 amino acid side chain mimics and their precursors were attached to the pyridine and benzene core with a special arrangement to produce potential peptidomimetics of omega-conotoxin MVIIA.