Maslinic acid as an effective anticancer agent

Lin X., ÖZBEY Ü., Sabitaliyevich U. Y., Attar R., Özçelik B., Zhang Y., ...More

CELLULAR AND MOLECULAR BIOLOGY, vol.64, no.10, pp.87-91, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 64 Issue: 10
  • Publication Date: 2018
  • Doi Number: 10.14715/cmb/2018.64.10.14
  • Journal Name: CELLULAR AND MOLECULAR BIOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.87-91
  • Keywords: Cancer, Signaling, Apoptosis, Maslinic Acid, CANCER CELLS, LUNG-CANCER, NATURAL-PRODUCTS, OLEANOLIC ACID, GASTRIC-CANCER, IN-VITRO, APOPTOSIS, SUPPRESSES, PROLIFERATION, TRITERPENES
  • Istanbul Technical University Affiliated: Yes

Abstract

Maslinic acid (2 alpha,3 beta-dihydroxyolean-12-en-28-oic acid) is a naturally occurring pentacyclic triterpenic compound. Maslinic acid is gradually gaining attention as an excellent pharmacologically active product because of its premium biological properties. In this review we will focus on chemopreventive properties of Maslinic acid against different cancers. Seemingly, available data is limited and we have yet to unravel how Maslinic acid therapeutically targeted oncogenic cell signal transduction cascades in different cancers. Moreover, there are visible knowledge gaps about the ability of Maslinic acid to modulate oncogenic and tumor suppressor microRNAs in various cancers.