IMMUNOLOGY LETTERS, vol.239, pp.1-11, 2021 (SCI-Expanded)
Article / Article
Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, CAB Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE, Veterinary Science Database
Helicobacter pylori, Immune checkpoint inhibitors, T-Lymphocytes, Stomach neoplasms, Ulcer, Gastritis, REGULATORY T-CELLS, NEUTROPHIL-ACTIVATING PROTEIN, HELICOBACTER-PYLORI, VACUOLATING CYTOTOXIN, EPITHELIAL-CELLS, VACA GENOTYPES, EXPRESSION, IMMUNIZATION, INFECTION, RESPONSES
Istanbul Technical University Affiliated:
Background: The progression to gastric cancer has been linked to chronic infection with Helicobacter pylori (H. pylori). Immune checkpoint inhibitors (programmed cell death -1, PD-1; programmed cell death -ligand 1, PD-L1) have a role in cancer immune escape. The relationship between H. pylori virulence factors with PD-1, PD-L1 T helper 1 (Th1), T helper 17 (Th17), and regulatory T cell (Treg) response genes, has not been thoroughly investigated in the development of gastric cancer. Therefore, we evaluated how H. pylori virulence factors influence the expression levels of immune-related genes in the development of gastric immunopathology.