The crosstalk between H. pylori virulence factors and the PD1:PD-L1 immune checkpoint inhibitors in progression to gastric cancer

Aydin E. M., Demir T. D., Seymen N., Said S. S., ÖKTEM OKULLU S., TIFTIKCI A., ...Daha Fazla

IMMUNOLOGY LETTERS, cilt.239, ss.1-11, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 239
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1016/j.imlet.2021.06.009
  • Dergi Adı: IMMUNOLOGY LETTERS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, CAB Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.1-11
  • Anahtar Kelimeler: Helicobacter pylori, Immune checkpoint inhibitors, T-Lymphocytes, Stomach neoplasms, Ulcer, Gastritis, REGULATORY T-CELLS, NEUTROPHIL-ACTIVATING PROTEIN, HELICOBACTER-PYLORI, VACUOLATING CYTOTOXIN, EPITHELIAL-CELLS, VACA GENOTYPES, EXPRESSION, IMMUNIZATION, INFECTION, RESPONSES
  • İstanbul Teknik Üniversitesi Adresli: Evet

Özet

Background: The progression to gastric cancer has been linked to chronic infection with Helicobacter pylori (H. pylori). Immune checkpoint inhibitors (programmed cell death -1, PD-1; programmed cell death -ligand 1, PD-L1) have a role in cancer immune escape. The relationship between H. pylori virulence factors with PD-1, PD-L1 T helper 1 (Th1), T helper 17 (Th17), and regulatory T cell (Treg) response genes, has not been thoroughly investigated in the development of gastric cancer. Therefore, we evaluated how H. pylori virulence factors influence the expression levels of immune-related genes in the development of gastric immunopathology.