Effect of Different Phosphorus Precursors on Biomimetic Hydroxyapatite Powder Properties

Karakas A., Yoruc A. B. H., Gokce H., Karabulut A., Erdogan D. C.

ACTA PHYSICA POLONICA A, vol.123, no.2, pp.418-420, 2013 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 123 Issue: 2
  • Publication Date: 2013
  • Doi Number: 10.12693/aphyspola.123.418
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.418-420
  • Istanbul Technical University Affiliated: Yes


Hydroxyapatite is the main component of natural hard tissues, such as teeth and bone. It has been studied extensively as a candidate biomaterial for its use in prosthetic applications. Hydroxyapatite was formulated as Ca-10(PO4)(6)(OH)(2) and it has a high stability under physiological conditions. Also hydroxyapatite can be synthesized using different calcium and phosphorus precursors. In this study, biomimetic hydroxyapatite powder has been synthesized simulating physiological conditions. Synthetic body fluids which have the same composition as human blood plasma instead of pure water were used as precipitation media to obtain biological conditions. Recent research involved the effect of different Ca-precursors however aim of this study is to determine the effect of phosphorus resources. In this study, the synthesis of hydroxyapatite powder is carried out by using biomimetic method in synthetic body fluids. Calcium acetate [Ca(CH3COO)(2), CA] and diammonium hydrogen phosphate [(NH4)(2)HPO4, DAHP], ammonium dihydrogen phosphate [NH4H2PO4, ADHP], dipotassium hydrogen phosphate [K2HPO4, DPHP] and orthophosphoric acid [H3PO4, OPA] were used as Ca- and P-precursors. Chemical structures of synthesized powders have been examined by Fourier transform infrared and X-ray diffraction. Results showed that synthesized powders have a pure hydroxyapatite structure. However, ADHP precursors have an unfavorable effect on sintered hydroxyapatite powders. Using ADHP phase transition was caused in pure hydroxyapatite structure and apatite and whitlockite were observed as secondary phases. Their particle size, surface area determination and morphological structures have been characterized by Zeta-Sizer, biomimetic hydroxyapatite the Brunauer-Emmett-Teller analysis and scanning electron microscopy images, respectively. As a result different starting materials have affected the structure, particle size and morphological properties of biomimetic hydroxyapatite. DOI: 10.12693/APhysPolA.123.418