Pollution by plastics and antibiotics are emerging issues in the areas of the environment and human health. In recent years, several studies have documented the widespread occurrence of plastic particles in various environmental, as well as human, systems, and much research has focused on possible interactions of contaminants with microplastics. Thus, the co-occurrence of plastics and antibiotics has caused another global problem for the environment and human health. Therefore, we focused on the current knowledge in the field of the co-occurrence of plastics and antibiotics to summarize the available studies. In this review, categorization of the topics, contaminants details, such as polymer type, size and source, antibiotic type, and other experimental parameters were summarized and discussed. This study indicated that the sorption of antibiotics on plastics, antibiotic susceptibility in the presence of plastics, and antibiotic resistance gene onto plastics were the most frequently examined categories in this field. Moreover, the variability in the procedures and the processes, and the heterogeneity data of reporting between different studies on similar topic make it difficult to bring all results together and produce a comprehensive picture of the current knowledge. Therefore, it is suggested that further research should be done using this systematic study.