Assessment of antiangiogenic effect of imatinib mesylate on vestibular schwannoma tumors using in vivo corneal angiogenesis assay Laboratory investigation

Yener U., Avsar T., Akgun E., Seker A., BAYRİ Y., Kilic T.

JOURNAL OF NEUROSURGERY, cilt.117, sa.4, ss.697-704, 2012 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 117 Konu: 4
  • Basım Tarihi: 2012
  • Doi Numarası: 10.3171/2012.6.jns112263
  • Dergi Adı: JOURNAL OF NEUROSURGERY
  • Sayfa Sayıları: ss.697-704

Özet

Object. Angiogenesis and the platelet-derived growth factor (PDGF) pathway are active in the pathogenesis of vestibular schwannomas (VSs). The purpose of this study was to test whether imatinib mesylate (Gleevec), a PDGF receptor (PDGFR) blocker, reduces angiogenic capacity in sporadic VS and in VS associated with neurofibromatosis Type 2 (NF2) using a conical angiogenesis assay.