Assessment of antiangiogenic effect of imatinib mesylate on vestibular schwannoma tumors using in vivo corneal angiogenesis assay Laboratory investigation


Yener U., Avsar T., Akgun E., Seker A., BAYRİ Y., Kilic T.

JOURNAL OF NEUROSURGERY, cilt.117, sa.4, ss.697-704, 2012 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 117 Sayı: 4
  • Basım Tarihi: 2012
  • Doi Numarası: 10.3171/2012.6.jns112263
  • Dergi Adı: JOURNAL OF NEUROSURGERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.697-704
  • İstanbul Teknik Üniversitesi Adresli: Hayır

Özet

Object. Angiogenesis and the platelet-derived growth factor (PDGF) pathway are active in the pathogenesis of vestibular schwannomas (VSs). The purpose of this study was to test whether imatinib mesylate (Gleevec), a PDGF receptor (PDGFR) blocker, reduces angiogenic capacity in sporadic VS and in VS associated with neurofibromatosis Type 2 (NF2) using a conical angiogenesis assay.