Graph neural network based unsupervised influential sample selection for brain multigraph population fusion

Kurucu M. C., Rekik I.

Computerized Medical Imaging and Graphics, vol.108, 2023 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 108
  • Publication Date: 2023
  • Doi Number: 10.1016/j.compmedimag.2023.102274
  • Journal Name: Computerized Medical Imaging and Graphics
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, Applied Science & Technology Source, BIOSIS, Biotechnology Research Abstracts, Compendex, Computer & Applied Sciences, EMBASE, INSPEC, MEDLINE
  • Keywords: Connectional brain templates, Graph neural networks, Multigraph population fusion, Sample selection, Unsupervised learning
  • Istanbul Technical University Affiliated: Yes


Graph neural networks (GNNs) have witnessed remarkable proliferation due to the increasing number of applications where data is represented as graphs. GNN-based multigraph population fusion methods for estimating population representative connectional brain templates (CBT) have recently led to improvements, especially in network neuroscience. However, prior studies do not consider how an individual training brain multigraph influences the quality of GNN training for brain multigraph population fusion. To address this issue, we propose two major sample selection methods to quantify the influence of a training brain multigraph on the brain multigraph population fusion task using GNNs, in a fully unsupervised manner: (1) GraphGradIn, in which we use gradients w.r.t GNN weights to trace changes in the centeredness loss of connectional brain template during the training phase; (2) GraphTestIn, in which we exclude a training brain multigraph of interest during the refinement process in the test phase to infer its influence on the CBT centeredness loss. Next, we select the most influential multigraphs to build the training set for brain multigraph population fusion into a CBT. We conducted extensive experiments on brain multigraph datasets to show that using a dataset of influential training samples improves the learned connectional brain template in terms of centeredness, discriminativeness, and topological soundness. Finally, we demonstrate the use of our methods by discovering the connectional fingerprints of healthy and neurologically disordered brain multigraph populations including Alzheimer's disease and Autism spectrum disorder patients. Our source code is available at