Numerical Study of Magnetic Drug Targeting Inside the Bifurcated Channel as a Simplified Model of Right Common Iliac Artery Using Fe3O4-Blood Magnetic Nanofluid


Motlagh S. Y., Deyhim S.

IRANIAN JOURNAL OF SCIENCE AND TECHNOLOGY-TRANSACTIONS OF MECHANICAL ENGINEERING, 2022 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Publication Date: 2022
  • Doi Number: 10.1007/s40997-022-00507-y
  • Journal Name: IRANIAN JOURNAL OF SCIENCE AND TECHNOLOGY-TRANSACTIONS OF MECHANICAL ENGINEERING
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, ABI/INFORM, Aerospace Database, INSPEC, Metadex
  • Keywords: Magnetic drug targeting, Magnetic nanofluid, Right common iliac artery, Buongiorno model, HEAT-TRANSFER, BLOOD-FLOW, NANOPARTICLES, DELIVERY, SIMULATION, VESSEL, FIELD, DOXORUBICIN, SYSTEM, FLUID
  • Istanbul Technical University Affiliated: Yes

Abstract

In the present work, a numerical study was carried out on the magnetic drug targeting (MDT) from the abdominal aorta to the target tissue that was considered in the right common iliac artery. Fe3O4 nanoparticles were used as drug carriers. The governing equations of continuity, momentum and modified Buongiorno's model for magnetic nanofluid volume fraction were discretized with finite volume method. For three different types of magnetic sources, problem was solved. Examination of the effect of nanoparticle diameter showed that at a diameter of 10 nm, the performance of MDT was improved by 250% compared to a 2-nm particle. Moreover, at constant nanoparticle diameters and magnetic fields, increasing the volume fraction from 0.2% to 2% resulted in a sixfold improvement in drug delivery performance. According to the results, in some cases, Kelvin force generates vortices inside the right common iliac artery, which prevent the drug from entering the target tissue. In general, the use of a magnetic field significantly increases the residence time of the drug on the target tissue.