CURCUMIN, INCREASING ITS WATER SOLUBILITY BY ULTRASOUND AND PEG

Catalgil Giz H. H., ISCI S., BAHADORI F., Kalaycioglu Z., Akkurt B.

SIGMA JOURNAL OF ENGINEERING AND NATURAL SCIENCES-SIGMA MUHENDISLIK VE FEN BILIMLERI DERGISI, vol.35, no.1, pp.47-58, 2017 (ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 35 Issue: 1
  • Publication Date: 2017
  • Journal Name: SIGMA JOURNAL OF ENGINEERING AND NATURAL SCIENCES-SIGMA MUHENDISLIK VE FEN BILIMLERI DERGISI
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Academic Search Premier, Directory of Open Access Journals
  • Page Numbers: pp.47-58
  • Keywords: Curcumin, solubility, ultrasound, complex formation, polyethylene glycol, AQUEOUS SOLUBILITY, FT-RAMAN, STABILITY, COMPLEXATION, ALGINATE, SPECTROSCOPY, ENHANCEMENT, CONJUGATION, CANCER, AGENT
  • Istanbul Technical University Affiliated: Yes

Abstract

Water solubility of curcumin is increased by PEG in ultrasound medium. Different PEG-curcumin complexes were prepared with and without using ultrasound at 25 degrees C. Curcumin concentrations of complexes were determined by UV. The surface charges of PEG-curcumin complexes were investigated by zeta measurements. Critical aggregate concentrations were determined from both UV and zeta potential measurements. Complexes prepared by ultrasound were found to be more compact and homogenous in both size and charge distribution and they also carried more curcumin. Antioxidant capacity of the complexes, determined by DPPH and FRAP methods, were higher than the capacity of curcumin itself.