Synthesis and characterization of metal complexes of acebutolol, atenolol, and propranolol antihypertension drugs


Gölcü A. , Yucesoy C., Serin S.

SYNTHESIS AND REACTIVITY IN INORGANIC AND METAL-ORGANIC CHEMISTRY, vol.34, no.7, pp.1259-1275, 2004 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 34 Issue: 7
  • Publication Date: 2004
  • Doi Number: 10.1081/sim-120039270
  • Title of Journal : SYNTHESIS AND REACTIVITY IN INORGANIC AND METAL-ORGANIC CHEMISTRY
  • Page Numbers: pp.1259-1275
  • Keywords: metal complexes, molar conductivity, transition metal ion, SCHIFF-BASE LIGANDS, PERFORMANCE LIQUID-CHROMATOGRAPHY, CHARGE-TRANSFER COMPLEXATION, SPECTROPHOTOMETRIC DETERMINATION, ANTIMICROBIAL ACTIVITY, COPPER(II) COMPLEXES, ZINC(II) COMPLEXES, CRYSTAL-STRUCTURE, CU(II), BINUCLEAR

Abstract

The complexation of two transition metal ions with the beta-blocker drugs acebutolol (HL1), atenolol (HL2), and propranolol (HL3) was studied in methanol and acetonitrile media at M:L (metal: ligand) molar ratio from 1:1 to 1:10. Cu(II) complexes with ligands having the stoichiometric ratio 1:4 (mononuclear copper(H) complexes) and 1:1 (binuclear copper(II) complexes) were prepared. The analytical data show that the metal to ligand ratio in the mononuclear Co(II) complexes was 1:2. The complexes were characterized on the basis of analytical data, magnetic moments, atomic absorption, infrared and electronic spectral data. Molar conductivities of the complexes at room temperature were measured. The conductivity values of the mononuclear Cu(II) complexes indicate weak electrolyte behavior, whereas the binuclear Cu(II) and mononuclear Co(II) complexes are non-electrolytes. The thermal properties of all complexes have been studied by the DTA and TG.