A 3D co-culture intestinal organoid system for exploring glucose metabolism


Nie J., Liao W., Zhang Z., Zhang M., Wen Y., Çapanoğlu Güven E., ...Daha Fazla

Current Research in Food Science, cilt.6, 2023 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 6
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1016/j.crfs.2022.11.021
  • Dergi Adı: Current Research in Food Science
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, EMBASE, Food Science & Technology Abstracts, Directory of Open Access Journals
  • Anahtar Kelimeler: 3D co-culture, Intestinal organoid, Glucose metabolism
  • İstanbul Teknik Üniversitesi Adresli: Evet

Özet

© 2022 The AuthorsMany treatments have been used for glucose metabolism diseases such as type 2 diabetes, and all of those treatments have several advantages as well as limitations. This review introduces a 3D co-culture intestinal organoid system developed from stem cells, which has the special function of simulating human tissues. Recent studies have revealed that the gut is an important site for exploring the interactions among glucose metabolism, gut microbial metabolism, and gut microbiota. Therefore, 3D intestinal organoid systems can be used to imitate the congenital errors of human gut development, drug screening, food transportation and toxicity analysis. The intestinal organoid system construction methods and their progress as compared with traditional 2D culture methods have also been summarised in the manuscript. This paper discusses the research progress in terms of intestinal organoids applicable to glucose metabolism and provides new ideas for developing anti-diabetic drugs with high efficiency and low toxicity.