The presence of microplastics in the indoor environment presents growing environmental and human health risks because of their physicochemical and toxic characteristics. Therefore, we aimed to isolate, identify, and characterize plastic debris in settled house floor dusts. This study is a rare study which assess the risks of plastic debris in settled house dust through multiple approaches including the estimated daily intake, pollution loading index, and polymer hazard index. The results indicated that polyethylene and polypropylene were the predominate polymer type of plastic debris in settled house dust with various shapes and colors. The risk assessment results also indicated the serious impact of microplastics in terms of extremely dangerous contamination as well as the fact that they present a polymer hazard. Results indicated that humans have a higher risk of exposure to microplastics via ingestion rather than inhalation. In addition, infants had a higher risk of potential intake compared to other age groups.