HLA DPB1 15:01 Allele Predicts Spontaneus Hepatitis B Surface Antigen Seroconversion


Katrinli Ş., Erkut G. N. K., Ozdil K., Enc F. Y., Ozturk O., Kahraman R., ...More

ACTA GASTRO-ENTEROLOGICA BELGICA, vol.80, no.3, pp.351-355, 2017 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 80 Issue: 3
  • Publication Date: 2017
  • Journal Name: ACTA GASTRO-ENTEROLOGICA BELGICA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED)
  • Page Numbers: pp.351-355
  • Istanbul Technical University Affiliated: Yes

Abstract

Aim : Chronic hepatitis B (CHB) is a global health problem. Recent genome-wide association studies (GWAS) exposed significant association between the human leukocyte antigen (HLA) class II region, including both DP and DQ loci, and chronic hepatitis B. Previous research also indicated the involvement of adaptive immune system in Hepatitis B seroconversion. The aim of this study is to investigate possible polymorphisms in the HLA-DP locus that can contribute to immune response to Hepatitis B virus (HBV).