HLA DPB1 15:01 Allele Predicts Spontaneus Hepatitis B Surface Antigen Seroconversion

Katrinli Ş., Erkut G. N. K., Ozdil K., Enc F. Y., Ozturk O., Kahraman R., ...Daha Fazla

ACTA GASTRO-ENTEROLOGICA BELGICA, cilt.80, sa.3, ss.351-355, 2017 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 80 Sayı: 3
  • Basım Tarihi: 2017
  • Dergi Adı: ACTA GASTRO-ENTEROLOGICA BELGICA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED)
  • Sayfa Sayıları: ss.351-355
  • İstanbul Teknik Üniversitesi Adresli: Evet

Özet

Aim : Chronic hepatitis B (CHB) is a global health problem. Recent genome-wide association studies (GWAS) exposed significant association between the human leukocyte antigen (HLA) class II region, including both DP and DQ loci, and chronic hepatitis B. Previous research also indicated the involvement of adaptive immune system in Hepatitis B seroconversion. The aim of this study is to investigate possible polymorphisms in the HLA-DP locus that can contribute to immune response to Hepatitis B virus (HBV).