The gradual onset of pain over the region of the lateral epicondyle can result in the Tennis Elbow condition that affects a significant number of people whose activities involve repetitive wrist movements. This study is the first effort so far to propose an experimental design based research to investigate the effects of different backhand grips of tennis players regarding the onset of elbow pain. A sample population of tennis players is selected for implementing various tests using the same test measurements and evaluation conditions. Non-parametric variance analysis techniques fulfil the hypothesis test and derive inferential statistics of the research. The clear and significant differences among the evaluated grips prove that using a two-handed backhand style for backhand strokes is safer than other common grip styles.