Electrochemical oxidation of curcuminoids: an experimental and computational investigation


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Kalaycıoğlu Z., Karadas N., Çınar M. E., Aysil Ozkan S., Ozer Unal D., Gölcü A., ...Daha Fazla

TURKISH JOURNAL OF CHEMISTRY, cilt.43, sa.3, ss.834-853, 2019 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 43 Sayı: 3
  • Basım Tarihi: 2019
  • Doi Numarası: 10.3906/kim-1812-43
  • Dergi Adı: TURKISH JOURNAL OF CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.834-853
  • Anahtar Kelimeler: Cyclic voltammetry, curcuminoids, density functional theory, differential pulse voltammetry, VOLTAMMETRIC DETERMINATION, CARBON NANOTUBES, ELECTRODE, BEHAVIOR, ENERGIES, PRODUCTS, QUANTIFICATION, FLUORESCENCE, ANTIOXIDANT, MOLECULES
  • İstanbul Teknik Üniversitesi Adresli: Evet

Özet

Curcuminoids, reported to have important biological properties, such as antioxidant, anti-Alzheimer, and antidiabetic properties, comprise curcumin (CRM; 1,7-bis [4-hydroxy-3-methoxyphenyl]-1,6-heptadiene-3,5-dione) and its derivatives demethoxycurcumin (DMC; (E,6E)-1- (3,4-dimethoxy-cyclohexyl)-7- (3,4-dimethoxyphenyl) hepta-1,6-diene-3,5-dione) and bisdemethoxycurcumin (BDMC; 1,7-bis[4-hydroxypheny1]-1,6-heptadiene-3,5-dione). Their electrochemical oxidations are thoroughly explored by applying cyclic and differential pulse voltammetric techniques. The dependence of current intensities and potentials on pH, concentration, scan rate, and nature of the buffer was investigated. The outcome is supported by density functional theory computations indicating the transfer of 4-e(-)/H+, 6-e(-)/H-+,H- and 8-e(-)/H+ couples involved in the oxidation mechanisms of CRM, DMC, and BDMC, respectively, leading to the formation of the same oxidized product.