INTERLEUKIN-6 PRODUCTION BY HUMAN HEPATOMA LINES IS RELATED TO A LOW DEGREE OF CELL-DIFFERENTIATION


PAROLI M., CARLONI G., ALFANI E., DEPETRILLO G., BARNABA V.

RESEARCH IN VIROLOGY, vol.144, no.4, pp.323-326, 1993 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 144 Issue: 4
  • Publication Date: 1993
  • Doi Number: 10.1016/s0923-2516(06)80048-8
  • Title of Journal : RESEARCH IN VIROLOGY
  • Page Numbers: pp.323-326

Abstract

In this study, we showed by Northern blot analysis and bioassays that scarcely differentiated human hepatoma cell line HA22T/VGH constitutively produces interleukin-6 (IL6). This cytokine was produced neither by moderately differentiated Li7A nor by well-differentiated HepG2 human hepatoma cell lines. The finding that transcripts for IL6 were not present in 2.2.15 cells, a HepG2-derived clone transfected with the intracellular replicative form of hepatitis B virus (HBV) DNA, suggests that production of this cytokine is not affected by HBV-encoded gene products, but is more likely related to the dedifferentiated state of hepatoma cells.