Spectrophotometric determination of nifedipine via charge-transfer complexes


Gölcü A. , Serin S.

Scientia Pharmaceutica, vol.66, no.4, pp.341-349, 1998 (Journal Indexed in SCI Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 66 Issue: 4
  • Publication Date: 1998
  • Title of Journal : Scientia Pharmaceutica
  • Page Numbers: pp.341-349
  • Keywords: Charge-Transfer complexes, Nifedipine determination, Spectrophotometry, Vasodilating agents

Abstract

A simple and sensitive spectrophotometric method for the determination of Nifedipine is described, based on the formation of charge-transfer complex using tetrachloroquinone (chloranil) as Π-acceptor. This complex exhibit intense absorption bands in the electronic spectrum. The molecular ratio of the reactant in the complex was established and the experimental conditions leading to maximum charge-transfer band also studied. The proposed procedure has been applied successfully to pure sample and drug formulation with good accuracy. Beer's Law is obeyed over the concentration range 15,5 - 77,5 mg/100 mL for chloranil. The optimum experimental parameters for colour production with reagent were studied and incorporated into procedure.