In this study, an integrated approach of remote sensing and Geographic Information Systems (GIS) was used to investigate the spatial and temporal characteristics of the Kizilirmak Delta. It is a major wetland complex on the Black Sea coast, which has a very rich biodiversity and critical habitat for globally endangered bird species, and was announced as an RAMSAR protection site in Turkey. Main objectives of this study were: (1) determination of the land use/cover changes, (2) examination of the effects of these changes on environment, and (3) assessment of the human impacts on the environment. 1987 Landsat TM and 2004 Aster images, topographic maps, field survey, and other ancillary data have been used to perform the study objectives. The obtained results delineated that the Kizilirmak Delta has been considerably changed as a result of human activities between 1987 and 2004. Analysis of satellite images and other data sources in the GIS environment introduced the changes in the delta and their impacts on the environment.