The effect of HLA-DQB1 alleles on virologic breakthroughs during chronic hepatitis B treatment with genetically low barrier drugs

Doganay, Levent; TUNCER, İLYAS; Katrinli, Şeyma; Enc, Feruze; Ozturk, Oguzhan; ÇOLAK, YAŞAR; Ulasoglu, Celal; Dinler Doğanay, Gizem

doi:10.1016/j.clinre.2012.10.013

The effect of HLA-DQB1 alleles on virologic breakthroughs during chronic hepatitis B treatment with genetically low barrier drugs

Atıf İçin Kopyala

Doganay L., TUNCER İ., Katrinli Ş., Enc F. Y., Ozturk O., ÇOLAK Y., ...Daha Fazla

CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY, cilt.37, sa.4, ss.359-364, 2013 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 37 Sayı: 4
Basım Tarihi: 2013
Doi Numarası: 10.1016/j.clinre.2012.10.013
Dergi Adı: CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.359-364
İstanbul Teknik Üniversitesi Adresli: Evet

Özet

Background: Chronic hepatitis B treatment with oral antiviral drugs is a long course. During this course, antiviral resistance is a serious issue, particularly, if genetically low barrier drugs are in use. Host immunity is accepted to have an effect on antiviral resistance development. The earliest clinical sign of drug resistance is virologic breakthrough. In this study, we aimed to investigate the relation between HLA-DQB1 alleles and virologic breakthrough events.