The effect of HLA-DQB1 alleles on virologic breakthroughs during chronic hepatitis B treatment with genetically low barrier drugs

Doganay, Levent; TUNCER, İLYAS; Katrinli, Şeyma; Enc, Feruze; Ozturk, Oguzhan; ÇOLAK, YAŞAR; Ulasoglu, Celal; Dinler Doğanay, Gizem

doi:10.1016/j.clinre.2012.10.013

The effect of HLA-DQB1 alleles on virologic breakthroughs during chronic hepatitis B treatment with genetically low barrier drugs

Copy For Citation

Doganay L., TUNCER İ., Katrinli Ş., Enc F. Y., Ozturk O., ÇOLAK Y., ...More

CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY, vol.37, no.4, pp.359-364, 2013 (SCI-Expanded)

Publication Type: Article / Article
Volume: 37 Issue: 4
Publication Date: 2013
Doi Number: 10.1016/j.clinre.2012.10.013
Journal Name: CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.359-364
Istanbul Technical University Affiliated: Yes

Abstract

Background: Chronic hepatitis B treatment with oral antiviral drugs is a long course. During this course, antiviral resistance is a serious issue, particularly, if genetically low barrier drugs are in use. Host immunity is accepted to have an effect on antiviral resistance development. The earliest clinical sign of drug resistance is virologic breakthrough. In this study, we aimed to investigate the relation between HLA-DQB1 alleles and virologic breakthrough events.