The effect of HLA-DQB1 alleles on virologic breakthroughs during chronic hepatitis B treatment with genetically low barrier drugs


Doganay L., TUNCER İ., Katrinli Ş. , Enc F. Y. , Ozturk O., ÇOLAK Y., ...More

CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY, vol.37, no.4, pp.359-364, 2013 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 37 Issue: 4
  • Publication Date: 2013
  • Doi Number: 10.1016/j.clinre.2012.10.013
  • Title of Journal : CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY
  • Page Numbers: pp.359-364

Abstract

Background: Chronic hepatitis B treatment with oral antiviral drugs is a long course. During this course, antiviral resistance is a serious issue, particularly, if genetically low barrier drugs are in use. Host immunity is accepted to have an effect on antiviral resistance development. The earliest clinical sign of drug resistance is virologic breakthrough. In this study, we aimed to investigate the relation between HLA-DQB1 alleles and virologic breakthrough events.