The cytokine response in THP-1 (monocyte) and HL-60 (neutrophil-differentiated) cells infected with different genotypes of Helicobacter pylori strains

Caliskan R., YAZGAN A. S., TOKMAN H. B., SOFYALI E., ERZIN Y. Z., AKGUL O., ...Daha Fazla

TURKISH JOURNAL OF GASTROENTEROLOGY, cilt.26, sa.4, ss.297-303, 2015 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 26 Sayı: 4
  • Basım Tarihi: 2015
  • Doi Numarası: 10.5152/tjg.2015.8058
  • Dergi Adı: TURKISH JOURNAL OF GASTROENTEROLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.297-303
  • Anahtar Kelimeler: H. pylori, cagA, vacA, babA, cytokine response, GASTRIC EPITHELIAL-CELLS, OUTER-MEMBRANE PROTEINS, NECROSIS-FACTOR-ALPHA, INTERLEUKIN-8 PRODUCTION, IMMUNE-RESPONSE, EXPRESSION, CAGA, PATHOGENESIS, STIMULATION, VACA
  • İstanbul Teknik Üniversitesi Adresli: Evet

Özet

Background/Aims: Helicobacter pylori (H. pylori) is a microaerophilic bacterium related with peptic ulcer and gastric cancer. Its virulence factors include cytotoxin-associated gene A (CagA) and vacuolating cytotoxin gene A (VacA) proteins. Cytokine release inducted by H. pylori colonization has an important role in pathogenesis of H. pylori. The severity of gastric pathologies depends on the H. pylori genotypes found in different geographical regions. We aimed to determine the relationship between different H. pylori genotypes and their effects on the cytokine release levels.