TURKISH JOURNAL OF GASTROENTEROLOGY, vol.26, no.4, pp.297-303, 2015 (SCI-Expanded)
Article / Article
TURKISH JOURNAL OF GASTROENTEROLOGY
Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
H. pylori, cagA, vacA, babA, cytokine response, GASTRIC EPITHELIAL-CELLS, OUTER-MEMBRANE PROTEINS, NECROSIS-FACTOR-ALPHA, INTERLEUKIN-8 PRODUCTION, IMMUNE-RESPONSE, EXPRESSION, CAGA, PATHOGENESIS, STIMULATION, VACA
Istanbul Technical University Affiliated:
Background/Aims: Helicobacter pylori (H. pylori) is a microaerophilic bacterium related with peptic ulcer and gastric cancer. Its virulence factors include cytotoxin-associated gene A (CagA) and vacuolating cytotoxin gene A (VacA) proteins. Cytokine release inducted by H. pylori colonization has an important role in pathogenesis of H. pylori. The severity of gastric pathologies depends on the H. pylori genotypes found in different geographical regions. We aimed to determine the relationship between different H. pylori genotypes and their effects on the cytokine release levels.