Glassy dynamics of protein folding

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Tuzel E., Erzan A.

PHYSICAL REVIEW E, vol.61, no.2, 2000 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 61 Issue: 2
  • Publication Date: 2000
  • Doi Number: 10.1103/physreve.61.r1040
  • Journal Name: PHYSICAL REVIEW E
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Istanbul Technical University Affiliated: No


A coarse-grained model of a random polypeptide chain, with only discrete torsional degrees of freedom and Hookean springs connecting pairs of hydrophobic residues is shown to display stretched exponential relaxation under Metropolis dynamics at low temperatures with the exponent beta similar or equal to 1/4, in agreement with the best experimental results. The time dependent correlation functions for fluctuations about the native state, computed in the Gaussian approximation for real proteins, have also been found to have the same functional form. Our results indicate that the energy landscape exhibits universal features over a very large rang of energies and is relatively independent of the specific dynamics.