Recent advances on the improvement of quercetin bioavailability

Kandemir K., Tomas M., McClements D. J., Çapanoğlu Güven E.

TRENDS IN FOOD SCIENCE & TECHNOLOGY, cilt.119, ss.192-200, 2022 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 119
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1016/j.tifs.2021.11.032
  • Dergi Adı: TRENDS IN FOOD SCIENCE & TECHNOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, Analytical Abstracts, Aquatic Science & Fisheries Abstracts (ASFA), Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, Food Science & Technology Abstracts, Veterinary Science Database, DIALNET
  • Sayfa Sayıları: ss.192-200
  • Anahtar Kelimeler: Quercetin, Bioavailability, Solubility, Encapsulation, Co-crystallization, IN-VITRO, EXCIPIENT EMULSIONS, NUTRACEUTICAL BIOAVAILABILITY, ZEIN NANOPARTICLES, PLASMA QUERCETIN, ORAL DELIVERY, STABILITY, ANTIOXIDANT, BIOACCESSIBILITY, ENCAPSULATION
  • İstanbul Teknik Üniversitesi Adresli: Evet

Özet

Background: Natural antioxidants, such as polyphenols, are finding increasing application in functional foods designed to improve human health, wellbeing, and performance. Quercetin is a flavonol-based polyphenol that exhibits a broad range of potentially beneficial health effects, including anti-hypertensive, anti-diabetic, antiasthmatic, anti-carcinogenic, anti-viral and antioxidant activities. The types and amounts of quercetin found in different plant sources vary considerably. Onions have a particularly high quercetin content, mainly in the form of isoquercetin, whereas black teas and apples mainly contain quercetin in the form of rutin.Scope and approach: Quercetin has been incorporated into different kinds of food matrices to improve their nutritional profiles, including baked goods and dairy products. However, the bioavailability of quercetin is often relatively low (<10%) because of its poor water-solubility, chemical stability, and absorption profile. The bioavailability of quercetin depends on its chemical structure, physicochemical properties, and food matrix effects.Key findings and conclusions: A number of studies have shown that the bioavailability of quercetin can be improved by encapsulating it in well-designed colloidal delivery systems assembled from food-grade ingredients. This review summarizes the major factors affecting the bioavailability of quercetin, as well as approaches being developed to increase its bioavailability. Enhancing the bioavailability of quercetin may lead to the development of more effective nutraceuticals and functional foods.