In this paper, the application and design of a high-power factor isolated Cuk converter-based LED driver are realized for up to 50 W power. For the power switch of the PFC isolated Cuk converter, traditional Si and silicon carbide (SiC) MOSFETs, which are wide bandgap semiconductors, are used and compared. The application is conducted using a dsPIC30F4011 microcontroller including PI voltage control. A current sensor is added to limit maximum current. Moreover, PI control parameters are selected by genetic algorithm to avoid a complex mathematical procedure for controller design. The power LED model derived in this paper is used for the PI parameter selection process. In addition, the input side inductor of the converter is operated in discontinuous conduction mode, and the switching frequency of the power switch is 57 kHz. With the experimental setup, the total harmonic distortion (THD) of grid voltage and current, power LED voltage and current, switch voltage, and input side inductor current are shown for both the SiC and Si MOSFETs and compared. It is concluded from the application that the SiC-based driver gives better results than the Si-based driver on the basis of THD and efficiency. Further, both applications provide limits of IEC61000-3-2 C class standard.