The synthesis of pyrido(2,3,4-kl)acridine unit of some marine alkaloids


Ozturk T. , MCKILLOP A.

CANADIAN JOURNAL OF CHEMISTRY, vol.78, no.9, pp.1158-1164, 2000 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 78 Issue: 9
  • Publication Date: 2000
  • Doi Number: 10.1139/cjc-78-9-1158
  • Title of Journal : CANADIAN JOURNAL OF CHEMISTRY
  • Page Numbers: pp.1158-1164

Abstract

A simple and convenient synthesis of pyrido(2,3,4-kl)acridine (1), the main skeleton of some marine alkaloids, via cyclization and intramolecular nitrene insertion, is described. The importance of the planarity of the molecule during the nitrene insertion is explained.