Adequate hydraulic analysis of a multiple outlets pipelines is very important for the design and evaluation of irrigation systems. In this paper, an analytical direct design procedure for a single multiple outlets pipelines is presented. The proposed equations, taking into consideration the influence of local energy loss, are suitable for designing laterals and manifolds in both trickle and sprinkler irrigation systems, and can be applied for various types of outlet, different flow regimes, and uniform line slope ranges. In this analytical procedure, for any desired uniformity level and given design slope range with remaining known parameters, the pipe diameter and the pipe length can then be directly designed. For any desired uniformity level, the procedure also provides an opportunity to evaluate the influence of local energy loss, as well as the influence of different uniform line slopes on the pipe geometric characteristics (pipe size and length), and on the corresponding hydraulic variables (operating inlet pressure head, downstream end pressure head, and total energy loss). Comparison test with a revised step-by-step numerical method for various slope combinations indicated that the presented methodology produces sufficiently accurate results for various design cases in both trickle and sprinkler lateral design. The methodology is simple, easy to apply, and useful for hydraulic analysis and direct design of a multiple outlets pipelines in irrigation subunits.