3D Composite scaffolds using strontium containing bioactive glasses

Erol M. M., OZYUGURAN A., OZARPAT O., KUCUKBAYRAK S.

JOURNAL OF THE EUROPEAN CERAMIC SOCIETY, vol.32, no.11, pp.2747-2755, 2012 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 32 Issue: 11
  • Publication Date: 2012
  • Doi Number: 10.1016/j.jeurceramsoc.2012.01.015
  • Journal Name: JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.2747-2755
  • Keywords: Scaffold, Sintering, Glass, Biomedical applications, IN-VITRO, CERAMIC SCAFFOLDS, HUMAN OSTEOBLASTS, BONE-FORMATION, 45S5, RANELATE, FRACTURE, CYTOCOMPATIBILITY, PROLIFERATION, ANGIOGENESIS
  • Istanbul Technical University Affiliated: Yes

Abstract

In this study, it was aimed to fabricate and characterize three-dimensional composite scaffolds derived from Sr-doped bioactive glass for bone tissue engineering applications. The scaffolds were fabricated by using polymer foam replication technique and coated with gelatin to be able to improve the properties of them. The porous scaffolds were successfully synthesized using optimized process parameters. Both coated and uncoated scaffolds favored precipitation of calcium phosphate layer when they were soaked in simulated body fluid (SBF). Gelatin coating improved the mechanical properties of the scaffold and also it did not change the bioactive behavior of the scaffold. It was observed that there was a good pore interconnectivity maintained in the scaffold microstructure. Results indicated that scaffolds can deliver controlled doses of strontium toward the SBF medium. That is the determinant for bone tissue regeneration, as far as strontium is known to positively act on bone remodeling. (c) 2012 Elsevier Ltd. All rights reserved.