Antibacterial Oil-Based Polyurethane Films for Wound Dressing Applications

Yucedag F., ATALAY-ORAL C., Erkal S., Sirkecioğlu A., Karasartova D., Sahin F., ...More

JOURNAL OF APPLIED POLYMER SCIENCE, vol.115, no.3, pp.1347-1357, 2010 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 115 Issue: 3
  • Publication Date: 2010
  • Doi Number: 10.1002/app.30788
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1347-1357
  • Keywords: biocompatibility, biomaterials, biopolymers, polyurethanes, renewable resources, SOYBEAN OIL, SILVER COATINGS, POLYOLS, POLYMERS, ACID, COPOLYMERIZATION
  • Istanbul Technical University Affiliated: Yes


As an alternative to petroleum-based polyol, hydroxyl containing material was prepared from linseed oil for polyurethane synthesis. Hexamethylene di-isocyanate (HMDI) and/or 4, 4'-methylene diphenyl cli-isocyanate (MDI) were used as isocyanate source. The polymerization reaction was carried out without catalyst. Polymer films were prepared by casting-evaporation technique. The MDI/ HMDI-based polyurethane and its films had higher T-g and better thermal property than that of the HMDI-based one because of the existence of benzene ring in the polymer chain. Static water contact angle was determined to be 74 degrees and 77.5 degrees for HMDI and MDI/HMDI-based films, respectively. Water adsorption was found to be around 2.6-3.6% for both films. In vitro degradation of polyurethanes in phosphate buffered saline at 37 degrees C was investigated by gravimetric method. Fourier transform infrared spectroscopy and scanning electron microscopy were used for confirmation of degradation on the polymer surface. The degradation rate of the HMDI-based polyurethane film was found higher than that of the MDI/HMDI-based film. Both the direct contact method and the MMT test were applied for determination of cytotoxicity of polymer films, and the polyurethane films investigated here was not cytotoxic. Silver-containing films were prepared using Biocera A (R) as filler and were screened for their antibacterial performance against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and/or Bacillus subtilis. The films prepared with and without Biocera A (R) exhibited antibacterial activity. (C) 2009 Wiley Periodicals, Inc. J Appl Polym Sci 115:1347-1357, 2010