In this study, bioactivity of glass and glass-ceramic in the system SiO2-CaO-Al2O3-P2O5-Na2O-MgO-CaF2 was investigated. The bioactivity of the resultant samples was analyzed by immersion study in simulated body fluid (SBF). Scanning electron microscopy (SEM-EDS), thin film X-ray diffraction (TF-XRD), ultraviolet spectroscopy (UV) and inductively coupled plasma (ICP) techniques were used to monitor changes in the glass and glass-ceramic surfaces and SBF composition. The results revealed that a hydroxyapatite (HA) layer was formed on the glass and glass-ceramic surfaces after 7 days and 1 day immersion, respectively. In addition, Al2O3 content of the bioactive glass and glass-ceramic improved the properties of the samples and did not cause a negative effect on the bioactivity of the samples. © 2013 American Scientific Publishers All rights reserved.